After obtaining a bachelor's degree in physics, Professor Michèle Desjardins turned her attention to the application of physics and engineering to the study of the brain. Her research focuses on three themes: the development of imaging methods and numerical models, and their application to the study of brain activity and neurovascular coupling. Recent projects focus on the evolution of neuronal and vascular networks with aging, oxygen distribution and radiosensitivity in tumors, the modulation of neurovascular coupling by noradrenaline, and the structure-function link in the brain.